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The principal objective of this study was to evaluate the frequency of bla BKC-1 by testing a collection of Klebsiella isolates.

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The carbapenemase was encoded by bla BKC-1which was located on a small nonconjugative plasmid 2. Methods for dilution ncm susceptibility tests for bacteria that grow aerobically; approved standard— 10th ed CLSI document MA To determine whether this plasmid was identical to p, the first plasmid identified as carrying bla BKC-1we performed whole-plasmid sequencing of the plasmid recovered from KpnJ.

BKC-1 Brazilian Klebsiella carbapenemase is a class A serine carbapenemase that was recently identified in Klebsiella pneumoniae icm from Brazil that belonged to sequence type ST clonal complex [CC] 2. To date, inactivation of mgrB has been the main mechanism of polymyxin resistance observed in K. Transformant cells were selected on LB agar plates supplemented with 0.

In this study, a jccm frequency of isolates carrying bla BKC-1 was observed and was mainly attributed to the persistence of a K. Address correspondence to Willames M. BKC-1 is a new class A serine carbapenemase that was recently identified in Klebsiella pneumoniae clinical isolates. The Klebsiella strains were isolated from different clinical specimens obtained between and Fig. Abstract BKC-1 is a new class A serine carbapenemase that was recently identified in Klebsiella pneumoniae clinical isolates.


A Map of Brazil, showing the geographic distribution of Klebsiella isolates that were investigated for the bla BKC-1 gene. Plasmid extraction of K. This article has been cited by other articles in PMC. Antimicrobial susceptibility testing was performed by the broth microdilution method, according to CLSI guidelines 45.

Kpn showed susceptibility to tigecycline MIC, 0. Clinical and Laboratory Standards Institute. Support Center Support Center. We verified that, in the absence of selective pressure, the plasmid harboring the bla BKC-1 gene, p, was unstable. These carbapenem resistance genes are frequently harbored on mobile genetic elements that are highly transmissible, contributing to the increasing frequency of carbapenem-resistant Enterobacteriaceae 1. Please review our privacy policy.

Antimicrobial susceptibility profiles of BKCproducing K. Antimicrob Agents Chemother Comparison of phenotypic tests for detecting BKCproducing Enterobacteriaceae isolates. Open in a separate window. The bla BKC-1 gene was inserted into a kb plasmid that was identical to the previously reported plasmid, p In the past decade, carbapenemase-encoding genes such as bla KPC-likebla OXAand bla NDM-like have emerged as jc, main mechanisms of carbapenem resistance in Enterobacteriaceae.

Sampaiob, c and Ana C.

To evaluate the stability of p harbored by the Kpn isolate, we performed serial passages of the Kpn isolate on Mueller-Hinton agar plates without the addition of antibiotic. The Kpn and KpnJ strains showed resistance to all beta-lactams and fluoroquinolones.

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During the experiments, it was observed that bla BKC-1 was easily lost in the absence of selective pressure. Only 2 BKCproducing K. S, sensitive; R, resistant. Published online Jul The Kpn and KpnJ strains showed different plasmid profiles.


Prepublished online May A total of Klebsiella strains collected from previous surveillance studies were randomly selected for this study, in order to represent distinct Brazilian geographic regions.

Ucm standards for antimicrobial susceptibility testing; 25th informational supplement. Journal List Antimicrob Agents Chemother v.

It is important to note that such new studies must search for bla BKC-1 using molecular techniques, since phenotypic tests may not accurately detect BKCproducing isolates 8. More studies with greater numbers of isolates from all Brazilian states are necessary to assess the real prevalence of isolates carrying bla BKC Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. The other authors have no conflicts to declare.

Frequency of BKCproducing Klebsiella species isolates.

Nicolettia Silvia R. These data might suggest that, although genetically related, the isolates were probably subjected to distinct selective pressures, which could have resulted in different OMP modifications. In addition, bla BKC-1 was harbored by a small unstable plasmid that could be easily lost in the absence of selective pressure.

Only 2 of Klebsiella isolates 0. Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. Santosb Jorge L.